top of page
This site was designed with the
.com
website builder. Create your website today.Start Now

DNA repair and epigenetic changes associated with Ageing and neurodegeneration

logo1_edited.png

DNA damage is one of the main causes of aging and age-associated diseases.

 Our lab focus is to:

  • Understand the molecular mechanisms of DNA repair (DSB).

  • The changes in epigenetic modifications resulting from DNA damage and aging.

  • The consequences of unrepaired DNA, DNA repair signaling and the epigenetic modifications particularly in the aging brains and neurodegeneration

We use SIRT6 as a model to understand the aging process. SIRT6 has important roles in longevity, cancer, neurodegeneration and more.

SIRT6 is an enzyme working both as DNA damage sensor and a chromatin remodeler affecting the epigenetic code and transcription regulation, and its absence has a deleterious effect from worms to humans

debbie_edited.jpg

Projects running in the lab:

projects in the lab.jpeg

Funding:

Logo_english_isf_mobile.png
erc_logo.png
338-3388025_ministry-of-magic-logo-png-p

The David and Inez Myers Foundation

bottom of page