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DNA repair and epigenetic changes associated with Ageing and neurodegeneration

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DNA damage is one of the main causes of aging and age-associated diseases.

 Our lab focus is to:

  • Understand the molecular mechanisms of DNA repair (DSB).

  • The changes in epigenetic modifications resulting from DNA damage and aging.

  • The consequences of unrepaired DNA, DNA repair signaling and the epigenetic modifications particularly in the aging brains and neurodegeneration

We use SIRT6 as a model to understand the aging process. SIRT6 has important roles in longevity, cancer, neurodegeneration and more.

SIRT6 is an enzyme working both as DNA damage sensor and a chromatin remodeler affecting the epigenetic code and transcription regulation, and its absence has a deleterious effect from worms to humans

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Projects running in the lab:

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Funding:

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The David and Inez Myers Foundation

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