Publications

Kaluski-Kopatch S, Stein D, Venzor AG, Campos AM, Planque M, Goldstein B, De Allende-Becerra E, Smirnov D, Zaretsky A, Eremenko E, Toiber D

SIRT6 regulates Tryptophan catabolism preventing metabolite imbalance and neurodegeneration.

https://orcid.org/0000-0001-6018-9296

Stein D, Portillo M, Kaluski-Kopatch S, Gallrein C, Garcia-Venzor A, Lachberg Y, Eremenko E, Smirnov D, Dror S, Einav M, Khrameeva E, Ben-Zvi A, Schumacher B, Toiber D.

SIRT6 regulates protein synthesis and folding through nucleolar remodeling.

https://doi.org/10.21203/rs.3.rs-4215918/v1

Zaretsky A, Venzor AG, Eremenko E, Stein D, Smirnov D, Rabuah Y, Dryer R, Kriukov D, Kaluski-Kopatch S, Einav M, Khrameeva E, Toiber D

SIRT6-dependent functional switch via K494 modifications of RE-1 silencing transcription factor.

Cell Death Dis. 2024 Nov 7;15(11):798

https://doi.org/10.1038/s41419-024-07160-0

PMID: 39511137; PMCID: PMC11543946

Kriukov D, Eremenko E, Smirnov D, Stein D, Tsitrina A, Golova A, Einav M, Khrameeva E, Toiber D

Nuclear expansion and chromatin structure remodeling in mouse aging neurons.

NAR Molecular Medicine. 2024 Jul;1(3):ugae011

https://doi.org/10.1093/narmme/ugae011

Portillo M, Toiber D

Tau’s function and dysfunction in the brain: when small changes have big consequences.

Neural Regeneration Research. 2024 Jan 1;19(1):152-3

https://doi.org/10.4103/1673-5374.373682

PMID: 37488858; PMCID: PMC10479848

Smirnov D, Toiber D, Gelfand M, Khrameeva E

optimalTAD: annotation of topologically associating domains based on chromatin marks enrichment.

bioRxiv. 2023:2023-03

https://doi.org/10.1101/2023.03.06.531254

Smirnov D, Eremenko E, Stein D, Kaluski S, Jasinska W, Cosentino C, Martinez-Pastor B, Brotman Y, Mostoslavsky R, Khrameeva E, Toiber D

SIRT6 is a key regulator of mitochondrial function in the brain.

Cell Death & Disease. 2023 Jan 18;14(1):35

https://doi.org/10.1038/s41419-022-05542-w

PMID: 36653345; PMCID: PMC9849342

Stein D, Slobodnik Z, Tam B, Einav M, Akabayov B, Berstein S, Toiber D

4-phenylbutyric acid-Identity crisis; can it act as a translation inhibitor?

Aging Cell. 2022 Nov 14:e13738

https://doi.org/10.1111/acel.13738

PMID: 36373957; PMCID: PMC9741500

Gorbunova V, Buschbeck M, Cambronne XA, Chellappa K, Corda D, Du J, Freichel M, Gigas J, Green AE, Gu F, Guberovic I, Jayabalan A, Khansahib I, Mukherjee S, Seluanov A, Simon MA, Sverkeli LJ, Kory N, Levine DC, Matic I, Nikiforov A, Rack JGM, Imai SI, Sinclair DA, Toiber D, Zhao Y, Mostoslavsky R, Kraus L, Guse AH

The 2021 FASEB science research conference on NAD metabolism and signaling.

Aging (Albany NY). 2021 Dec 9;13(23):24924–30

https://doi.org/10.18632%2Faging.203766

PMCID: PMC8714140

Sanhueza Salas LF, García-Venzor A, Beltramone N, Capurro C, Toiber D, Silberman DM

Metabolic Imbalance Effect on Retinal Müller Glial Cells Reprogramming Capacity: Involvement of Histone Deacetylase SIRT6.

Front Genet. 2021 Nov 4;12:769723

https://doi.org/10.3389/fgene.2021.769723

PMID: 34804128; PMCID: PMC8599966

Garcia-Venzor A, Toiber D

SIRT6 Through the Brain Evolution, Development, and Aging.

Front Aging Neurosci. 2021 Oct 13;13:747989

https://doi.org/10.3389/fnagi.2021.747989

PMID: 34720996; PMCID: PMC8548377

Jayaram DR, Frost S, Argov C, Liju VB, Anto NP, Muraleedharan A, Ben-Ari A, Sinay R, Smoly I, Novoplansky O, Isakov N, Toiber D, Keasar C, Elkabets M, Yeger-Lotem E, Livneh E

Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs.

Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2018899118

https://doi.org/10.1073/pnas.2018899118

Epub 2021 Sep 30. PMID: 34593629; PMCID: PMC8501901

Eremenko E, Golova A, Stein D, Einav M, Khrameeva E, Toiber D

FACS-based isolation of fixed mouse neuronal nuclei for ATAC-seq and Hi-C.

STAR Protoc. 2021 Jul 9;2(3):100643

https://doi.org/10.1016/j.xpro.2021.100643

PMID: 34308377; PMCID: PMC8283150

Mazor G, Smirnov D, Ben David H, Khrameeva E, Toiber D, Rotblat B

TP73-AS1 is induced by YY1 during TMZ treatment and highly expressed in the aging brain.

Aging (Albany NY). 2021 Jun 11;13(11):14843-14861

https://doi.org/10.18632/aging.203182

Epub 2021 Jun 11. PMID: 34115613; PMCID: PMC8221307

Naveh Tassa S, Ben Zichri S, Lacham-Hartman S, Oren O, Slobodnik Z, Eremenko E, Toiber D, Jelinek R, Papo N

A Mechanism for the Inhibition of Tau Neurotoxicity: Studies with Artificial Membranes, Isolated Mitochondria, and Intact Cells.

ACS Chem Neurosci. 2021 May 5;12(9):1563-1577

https://doi.org/10.1021/acschemneuro.1c00045

Epub 2021 Apr 27. PMID: 33904703

Portillo M, Eremenko E, Kaluski S, Garcia-Venzor A, Onn L, Stein D, Slobodnik Z, Zaretsky A, Ueberham U, Einav M, Brückner MK, Arendt T, Toiber D

SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis.

Cell Rep. 2021 Apr 27;35(4):109035

https://doi.org/10.1016/j.celrep.2021.109035

PMID: 33910019

Stein D, Mizrahi A, Golova A, Saretzky A, Venzor AG, Slobodnik Z, Kaluski S, Einav M, Khrameeva E, Toiber D

Aging and pathological aging signatures of the brain: through the focusing lens of SIRT6.

Aging (Albany NY). 2021 Mar 9;13(5):6420-6441

https://doi.org/10.18632/aging.202755

Epub 2021 Mar 9. PMID: 33690173; PMCID: PMC7993737

Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M

ARDD 2020: from aging mechanisms to interventions.

Aging (Albany NY). 2020 Dec 30;12(24):24484-24503

https://doi.org/10.18632/aging.202454

Epub 2020 Dec 30. PMID: 33378272; PMCID: PMC7803558.

Onn L, Portillo M, Ilic S, Cleitman G, Stein D, Kaluski S, Shirat I, Slobodnik Z, Einav M, Erdel F, Akabayov B, Toiber D

SIRT6 is a DNA double-strand break sensor.

Elife. 2020 Jan 29;9:e51636

https://doi.org/10.7554/eLife.51636

PMID: 31995034; PMCID: PMC7051178

Lan A, Stein D, Portillo M, Toiber D, Kofman O

Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos.

Behav Brain Funct. 2019 Mar 1;15(1):2

https://doi.org/10.1186/s12993-019-0153-3

PMID: 30823929; PMCID: PMC6397466

Gertman O, Omer D, Hendler A, Stein D, Onn L, Khukhin Y, Portillo M, Zarivach R, Cohen HY, Toiber D, Aharoni A

Directed evolution of SIRT6 for improved deacylation and glucose homeostasis maintenance.

Sci Rep. 2018 Feb 23;8(1):3538

https://doi.org/10.1038/s41598-018-21887-9

PMID: 29476161; PMCID: PMC5824787

Zorrilla-Zubilete MA, Yeste A, Quintana FJ, Toiber D, Mostoslavsky R, Silberman DM

Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6.

J Neurochem. 2018 Jan;144(2):128-138

https://doi.org/10.1111/jnc.14243

Epub 2017 Nov 21. PMID: 29049850

Shpak N, Manor R, Abilevich LK, Mantal O, Shavit K, Aflalo ED, Toiber D, Sagi A

Short versus long double-stranded RNA activation of a post-transcriptional gene knockdown pathway.

RNA Biol. 2017 Dec 2;14(12):1766-1775

https://doi.org/10.1080/15476286.2017.1356567

Epub 2017 Nov 3. PMID: 28816598; PMCID: PMC5731812

Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn JS, Abraham BJ, Namiki Y, Mansour M, Abdelfattah NS, Molodtsov A, Alexe G, Toiber D, de Waard M, Jain E, Boukhali M, Lion M, Bhere D, Shah K, Gutierrez A, Stegmaier K, Silverman LB, Sadreyev RI, Asara JM, Oettinger MA, Haas W, Look AT, Young RA, Mostoslavsky R, Dellaire G, Langenau DM

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.

Cancer Discov. 2017 Nov;7(11):1336-1353

https://doi.org/10.1158/2159-8290.CD-17-0267

Epub 2017 Oct 3. PMID: 28974511; PMCID: PMC5683427

Stein D, Toiber D

DNA damage and neurodegeneration: the unusual suspect.

Neural Regen Res. 2017 Sep;12(9):1441-1442

https://doi.org/10.4103/1673-5374.215254

PMID: 29089988; PMCID: PMC5649463

Kaluski S, Portillo M, Besnard A, Stein D, Einav M, Zhong L, Ueberham U, Arendt T, Mostoslavsky R, Sahay A, Toiber D

Neuroprotective Functions for the Histone Deacetylase SIRT6.

Cell Rep. 2017 Mar 28;18(13):3052-3062

https://doi.org/10.1016/j.celrep.2017.03.008

PMID: 28355558; PMCID: PMC5389893

Toiber D, Leprivier G, Rotblat B

Long noncoding RNA: noncoding and not coded.

Cell Death Discov. 2017 Jan 9;3:16104

https://doi.org/10.1038/cddiscovery.2016.104

PMID: 28090356; PMCID: PMC5220640

Toiber D, Erdel F, Bouazoune K, Silberman DM, Zhong L, Mulligan P, Sebastian C, Cosentino C, Martinez-Pastor B, Giacosa S, D'Urso A, Näär AM, Kingston R, Rippe K, Mostoslavsky R

SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.

Mol Cell. 2013 Aug 22;51(4):454-68

https://doi.org/10.1016/j.molcel.2013.06.018

Epub 2013 Aug 1. PMID: 23911928; PMCID: PMC3761390

Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.

Cell. 2012 Dec 7;151(6):1185-99

https://doi.org/10.1016/j.cell.2012.10.047

PMID: 23217706; PMCID: PMC3526953

Cohen-Kfir E, Artsi H, Levin A, Abramowitz E, Bajayo A, Gurt I, Zhong L, D'Urso A, Toiber D, Mostoslavsky R, Dresner-Pollak R

Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor.

Endocrinology. 2011 Dec;152(12):4514-24

https://doi.org/10.1210/en.2011-1128

Epub 2011 Sep 27. PMID: 21952235

Mulligan P, Yang F, Di Stefano L, Ji JY, Ouyang J, Nishikawa JL, Toiber D, Kulkarni M, Wang Q, Najafi-Shoushtari SH, Mostoslavsky R, Gygi SP, Gill G, Dyson NJ, Näär AM

A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development.

Mol Cell. 2011 Jun 10;42(5):689-99

https://doi.org/10.1016/j.molcel.2011.04.020

Epub 2011 May 19. PMID: 21596603; PMCID: PMC3119599

Toiber D, Sebastian C, Mostoslavsky R

Characterization of nuclear sirtuins: molecular mechanisms and physiological relevance.

Handb Exp Pharmacol. 2011;206:189-224

https://doi.org/10.1007/978-3-642-21631-2_9

PMID: 21879451

Toiber D, Azkona G, Ben-Ari S, Torán N, Soreq H, Dierssen M

Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.

Neurobiology of disease. 2010 Oct 1;40(1):348-59

https://doi.org/10.1016/j.nbd.2010.06.011

Epub 2010 Jun 30. PMID: 20600907

Greenberg DS, Toiber D, Berson A, Soreq H

Acetylcholinesterase variants in Alzheimer's disease: from neuroprotection to programmed cell death.

Neurodegener Dis. 2010;7(1-3):60-3

https://doi.org/10.1159/000285507

Epub 2010 Feb 18. PMID: 20173328

Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

Cell. 2010 Jan 22;140(2):280-93

https://doi.org/10.1016/j.cell.2009.12.041

PMID: 20141841; PMCID: PMC2821045

Toiber D, Greenberg DS, Soreq H

Pro-apoptotic protein-protein interactions of the extended N-AChE terminus.

J Neural Transm (Vienna). 2009 Nov;116(11):1435-42

https://doi.org/10.1007/s00702-009-0249-2

Epub 2009 Jun 16. PMID: 19533292; PMCID: PMC2773036

Toiber D, Berson A, Greenberg D, Melamed-Book N, Diamant S, Soreq H

N-acetylcholinesterase-induced apoptosis in Alzheimer's disease.

PLoS One. 2008 Sep 1;3(9):e3108